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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
E2F5
All Species:
15.45
Human Site:
S254
Identified Species:
24.29
UniProt:
Q15329
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15329
NP_001077057.1
346
37610
S254
D
D
L
T
Q
P
S
S
Q
S
L
T
P
V
T
Chimpanzee
Pan troglodytes
XP_511025
426
45548
S239
E
D
L
L
Q
S
P
S
A
V
S
T
P
P
P
Rhesus Macaque
Macaca mulatta
XP_001094919
346
37697
S254
D
D
L
T
Q
P
S
S
Q
S
L
T
P
A
T
Dog
Lupus familis
XP_853833
304
33793
S216
T
Q
P
S
S
Q
P
S
T
P
V
T
A
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
Q61502
335
36766
S244
D
D
L
T
Q
P
S
S
Q
S
S
T
S
V
T
Rat
Rattus norvegicus
Q62814
300
33206
V215
S
S
Q
S
S
T
S
V
T
P
P
K
S
T
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517985
227
25092
P141
L
T
Q
P
P
S
Q
P
Q
T
P
A
T
P
Q
Chicken
Gallus gallus
Q90977
403
43534
A313
A
S
P
L
L
H
S
A
Q
D
V
N
M
L
L
Frog
Xenopus laevis
NP_001086706
375
40890
P216
E
D
L
I
Q
A
P
P
A
V
P
S
T
P
Q
Zebra Danio
Brachydanio rerio
NP_998597
393
42365
S216
D
D
M
L
Q
N
L
S
T
P
A
S
T
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27368
805
87442
I572
Q
Q
H
Q
Q
P
S
I
Q
E
L
F
S
S
L
Honey Bee
Apis mellifera
XP_624285
300
34327
K215
S
F
T
F
R
P
P
K
G
I
S
K
P
D
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799123
356
39484
S264
V
A
T
P
T
P
V
S
V
I
P
V
A
E
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130952
446
48668
E335
T
I
S
M
D
S
L
E
N
P
R
T
P
L
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565831
483
52579
S371
P
A
C
L
P
I
A
S
S
S
G
S
T
G
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.8
97.9
78.9
N.A.
88.1
82.6
N.A.
57.2
33
58.1
56.2
N.A.
20.6
41
N.A.
51.9
Protein Similarity:
100
62.2
98.5
82.6
N.A.
90.1
84.3
N.A.
60.6
49.6
68.8
66.1
N.A.
29.6
55.2
N.A.
65.1
P-Site Identity:
100
40
93.3
13.3
N.A.
86.6
6.6
N.A.
6.6
13.3
20
26.6
N.A.
33.3
13.3
N.A.
13.3
P-Site Similarity:
100
46.6
93.3
26.6
N.A.
86.6
13.3
N.A.
13.3
33.3
33.3
46.6
N.A.
33.3
20
N.A.
13.3
Percent
Protein Identity:
N.A.
31.3
N.A.
28.1
N.A.
N.A.
Protein Similarity:
N.A.
45
N.A.
41.2
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
0
0
0
7
7
7
14
0
7
7
14
7
7
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
27
40
0
0
7
0
0
0
0
7
0
0
0
7
0
% D
% Glu:
14
0
0
0
0
0
0
7
0
7
0
0
0
7
0
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
7
0
0
7
0
% G
% His:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
7
0
7
0
7
0
7
0
14
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
7
0
0
0
14
0
0
7
% K
% Leu:
7
0
34
27
7
0
14
0
0
0
20
0
0
14
14
% L
% Met:
0
0
7
7
0
0
0
0
0
0
0
0
7
0
7
% M
% Asn:
0
0
0
0
0
7
0
0
7
0
0
7
0
0
0
% N
% Pro:
7
0
14
14
14
40
27
14
0
27
27
0
34
20
20
% P
% Gln:
7
14
14
7
47
7
7
0
40
0
0
0
0
7
14
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% R
% Ser:
14
14
7
14
14
20
40
54
7
27
20
20
20
7
7
% S
% Thr:
14
7
14
20
7
7
0
0
20
7
0
40
27
14
20
% T
% Val:
7
0
0
0
0
0
7
7
7
14
14
7
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _